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DISRUPTIVE CIRCADIAN RHYTHMS AND T2DM As the circadian system also affects cardiovascular physiology, kidney function, and glycemic status [144], the clinical impact of circadian disruption on the risk of complications in diabetes is an interesting subject for researchers

C., Diaz, C., Marticorena, E

Side effects, when they occur, are typically mild and temporary: Possible minor pinpoint bleeding during treatment Dramatically smoother with reduced texture irregularities Temporary dryness or flaking as skin renews Rare bruising in very sensitive individuals Serious complications are extremely rare when treatments are performed correctly in a medical setting by trained professionals

see full prescribing information for conversion to monotherapy (2.2)