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For instance, berberine can improve doxorubicin uptake in tumor tissues while simultaneously down-regulate the protein expression of P-gp and MRP1 in breast cancer

Adamowicz, E

Heinz H, Pramanik C, Heinz O, Ding Y, Mishra RK, Marchon D, et al

FIGURE 1 This primary mechanism of brain Se uptake was postulated based on mice transgenic studies (first of all, using Selenop / mice) and is relatively well explored by now