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The high-affinity GHBP consists of the extracellular domain of the hepatic GH receptor, and this binds the 22 kDa GH isoform preferentially (303)

588-590 A placebo-controlled crossover trial in 21 healthy middle-aged volunteers found a single dose of 302 mg decaffeinated green coffee extract (but not higher doses) improved blood vessel function up to 24 hours post-dose

Also, NOX1 and NOX4 knock-out mice are doing well and have no obvious signs of disease, suggesting that pharmacological inhibition of these NOX isoforms should be well tolerated

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