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I have PA and my 15 year old daughter has recently been displaying symptoms - utter exhaustion to the point where she was falling asleep at 4.30pm and sleeping through to the following morning day after day

Supplementary Information ESM 1 (download DOCX (DOCX 32 kb) Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made

By inhibiting NNMT, 5-Amino-1MQ effectively removes that brake, allowing for increased levels of nicotinamide adenine dinucleotide (NAD+) within the cell