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In addition to PHGDH, serine hydroxymethyltransferase (SHMT) is also implicated in tumorigenesis

Hormonal fluctuationsparticularly in estrogen and cortisolmay further modulate excitability and plasticity, adding variance to ctDCS outcomes (106)

4 Cellular and molecular mechanisms underlying TB-DM comorbidity The varying global incidences of TB-DM and the notable impact of DM on the clinical presentation, outcomes, and transmission of TB underscore a complex and intricate synergy between these conditions

Furthermore, the immune suppression caused by mycotoxins can make patients highly susceptible to chronic viral reactivations (like Epstein-Barr Virus) and tick-borne infections (like Lyme disease), which are frequently seen in the ME/CFS and Long COVID populations