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Se inadequacy has been implicated in growth faltering and changes in bone metabolism which can impact bone and cartilage development (Reference Cao, Gregoire and Zeng13Reference Zeng, Cao and Combs15)

Hence, the significant decrease in the rate of ALA synthesis in ntrc and ntrc/trxf1 mutants can be explained by decreased amounts of GluTR and GSAAT as the result of a relative lack of reductants

This dynamic feature also causes disengagement of F23 Cagri , and a loss of map density for the peptide residues proximal to Y149 1.40 (Supplementary Fig