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For CME_a, the key residues in the C1 region, N259 and E255, are crucial for its binding, further emphasizing the importance of the C1 region in mTYR (Table 4)

Importantly, it has been proposed that under some circumstances, especially in the presence of high concentrations of IFN-, the major immunosuppressive activity of activated DCs may be mediated to a greater extent by the expression and release of sHLA-G than by IDO (114)

For multiple comparisons of variables, one-way ANOVA followed by Tukeys post hoc test was conducted, and two-way ANOVA was used for analyses involving two independent variables

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