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doi: 10.3945/ajcn.113.065789 129 PoutonCWPorterCJ

"The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations"

This reduction in NAD decreases ATP production and leads to defects in DNA repair, as NAD is essential for PARP-1 activity, which increases the accumulation of genetic damage and potentially contributes to the development of neurodegenerative diseases (198, 208)