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Kawahata I, Fukunaga K (2020) Degradation of tyrosine hydroxylase by the ubiquitin-proteasome system in the pathogenesis of parkinsons disease and dopa-responsive dystonia

Tophi commonly develop in osteoarthritic toe and hand joints, suggesting roles of trauma, altered hydration (swelling) and connective tissue matrix structure and turnover ( Figure 1 - 8 )