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Key Insights: Generally well-tolerated Low toxicity in studies Non-addictive profile However: Not FDA-approved in many regions Quality and sourcing matter Who Should Avoid: Pregnant individuals People with medical conditions Those without guidance Concerned about safety

Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with 50 IC s of 24 and 11 nM in cell-based assays, respectively

PET tracers can be used to target NMDARs and AMPARs and can help facilitate both drug development and the pharmacokinetic profiling of candidate drugs [109]