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This accelerated energy generation is crucial for supporting the uncontrolled proliferation of tumor cells, especially under the high metabolic demands associated with KRAS mutations

J Cell Mol Med 2004

A family of drug transporters: the multidrug resistance-associated proteins

161 Beyond immune cell recruitment, hepatocyte-derived cholic acid triggers the release of Hedgehog ligands by HSCs, initiating Hedgehog signaling and promoting hepatocyte proliferation