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Standard dosing Daily dose: 300-600mcg per day Injection frequency: Once daily, preferably in the morning on an empty stomach Administration route: Subcutaneous injection Most users start at 300mcg to assess tolerance, then increase to 500-600mcg if the lower dose is well-tolerated but results are modest

Some of these CD38-specific hcAbs have been shown to inhibit the GDPR cyclase activity of CD38, while others induce mechanisms of cytotoxicity in mouse tumor models [91]

In a 9-month monkey oral toxicity study, all female monkeys in the high-dose group showed minimal-to-slight periportal hepatocyte vacuolation

There is also the issue of muscle loss