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[,] The liver and extrahepatic tissues or organs form a single line or multi-dimensional connection, which is directly based on anatomy, or mediated by the neuro-humoral factors, or caused by the pathogenic factors and others, thus forming a complex pan-liver network that is crucial for maintaining homeostasis and pathogenesis of disease

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DOI: 10.1016/S1877-1173(09)87015-4 Pei, L., Evans, R.M