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Despite B cells playing a key role in the SLE pathogenesis, B cell depletion with current monoclonal antibodies such as belimumab fails to achieve symptom remission in many lupus patients ( Initially, studies in murine models of SLE showed efficacy of anti-CD19 CAR-T therapy in B-cell depletion and reduction of disease progression ( Long-term follow-up of 8 SLE patients, including the previously mentioned patient, demonstrated significant progress with CD19 CAR-T therapy

166 XuJ.TianY.-S.XingX.-J.PengR.-H.ZhuB.GaoJ.-J.et al (2016)

This shift in perspective followed comprehensive single-cell transcriptomic studies, which revealed that astrocytes differ in function and gene expression, depending on the specific environmental stressors and pathological conditions (Liddelow et al., 2017

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