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doi: 10.1034/j.1600-0706.2000.880110.x 47 BarrientosABarrosMHValnotIRtigARustinPTzagoloffA

These histopathological results confirm that the reduced swimming speed and weaker muscle endurance observed in the LMNA mutant transgenic fish are indeed associated with the presence of abnormal muscle development

Based on the positive results of this study, a next-generation DNA vaccine has been developed using residual patient tumor and blood samples from patients vaccinated in the phase III clinical study