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Dose-dependent increases in the expression of AST (indirectly regulated by Nrf2) and direct Nrf2 target genes, including those encoding ferritin and GGT, were observed across omaveloxolone dose ranges of 20160 mg QD at 4 weeks, with AST elevation being maximal at 160 mg QD, which correlated with maximum response (i.e., greatest improvement in mFARS) at this dose [19]