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As a novel and effective approach distinct from dietary interventions and probiotic supplementation, FMT directly alters the gut microbiota composition and has been explored for the treatment of various microbiota-related disorders, including Clostridium difficile infection ( Recent evidence suggests that intragastric administration of Blautia wexlerae to a mouse model exposed to high-altitude hypoxia significantly increased arterial oxygen partial pressure, improved pulmonary arterial pressure, right ventricular systolic pressure, and lung injury scores

2012;7:e33853

Pyruvate dehydrogenase complex deficiency results in impaired conversion of pyruvate to acetyl-CoA, reduced production of citrate, and, therefore, impairment of the TCA cycle, leading to severe energy deficits (especially in the CNS)

ROS as signalling molecules: Mechanisms that generate specificity in ROS homeostasis