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Therefore, it would be rational to administer corticosteroids simultaneously with other topical agents for melasma treatment (Menter, 2004

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Icariin demonstrates a protective effect against gentamicin-induced ototoxicity in HEI-OC1 cells and cochlear explants through AMPK-SIRT3 signaling cascade activation, thereby offering a novel approach for addressing ototoxicity resulting from aminoglycoside antibiotics (Hu and Ma 2021)