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This is the catch-22 we discussed earlier in the article

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In experimental models, AOD-9604 peptide demonstrated a reduction in the expression of inflammatory markers directly involved in the destruction of articular cartilage

The decline of NAD + with age results from three converging factors: (1) increased activity of CD38, a NADase whose expression increases with age-related chronic inflammation (inflammaging), (2) reduced biosynthesis via the NAMPT (nicotinamide phosphoribosyltransferase) and NMN pathways, and (3) increased demand for NAD+ by PARP-1 to repair increasing oxidative DNA damage