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The lowered threshold to pain is caused by abnormalities of CNS processing of sensory stimuli by the brain, and is not caused by any primary muscle or soft-tissue dysfunction

One approach to correct the defect in Cl and water transport across the airway epithelium using a purinergic receptor P2Y purinoceptor 2 (P2Y2) receptor agonist to activate alternative Cl channels was expected to result in hydrated airway surface fluid and improved mucociliary clearance

As for the Janus kinase/signal transducer and activator of transcription (JAK/STAT) axis, direct evidence of modulation by PDEVs is currently limited, with most insights deriving from plant-derived compounds such as loganin [151]

Perhaps most notably, a basolateral transporter responsible for the efflux of ergothioneine in polarised cells such as enterocytes and proximal tubules cells of the liver has yet to be identified