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Subgroup analysis of those subjects having reduced corneal nerve fibers, and therefore more definitive evidence of small fiber neuropathy (37), show that ARA 290 treatment is associated with an increase in corneal nerve fiber density, analogous to the improvement seen after improved metabolic control (42) and after simultaneous pancreas and kidney transplantation (43)

At 2mg/mL, the amount is pharmacologically modest and is not expected to produce systemic niacinamide effects

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Quick Reference: Common Concentrations IU = insulin units on a U-100 syringe (100 IU = 1mL)