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120 In myeloid cell-specific SIRT1 knockout mice, lipid toxicity or LPS stimulation induced more severe hepatic inflammation, elevated pro-inflammatory cytokine levels, and enhanced M1 macrophage polarization, highlighting the critical role of SIRT1 in preserving immune balance

Indeed, mutations in mtDNA or impairment to the ETC cause mitochondrial dysfunction and energy depletion

Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology Clinical Practice Guideline

doi: 10.1016/j.biopha.2022.113395 161 van de DonkNRichardsonPGMalavasiF