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10.1038/s41556-022-01071-y 14 DongS.DuY.WangH.YuanW.AiW.LiuL

A quick overview of what well cover in this post: What is the IontoPatch

Collectively, the synergistic action of AGE-RAGE signaling, metabolic rewiring, and oxidative stress in the DW microenvironment creates a powerful, self-reinforcing circuit that locks macrophages into a persistent M1 state, thereby perpetuating chronic inflammation and impeding the resolution of healing (Figure 3)