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For instance, it remains unknown whether FSP1 or DHODH compensates for GPX4 deficiency in RCC subtypes [e.g., ccRCC with GPX4 silencing (227)] or if their dysregulation contributes to ferroptosis resistance

Functions of Glutathione Glutathione plays a multifaceted role in the body, supporting various essential functions: Neutralizes Free Radicals Protects cells from oxidative damage caused by pollution, UV radiation, and stress

Iron uptake in tumor cells primarily relies on TFR1 and DMT1 ( 3+

Ogrodnik M, Miwa S, Tchkonia T, Tiniakos D, Wilson CL, Lahat A, Day CP, Burt A, Palmer A, Anstee QM, Grellscheid SN, Hoeijmakers JHJ, Barnhoorn S, Mann DA, Bird TG, Vermeij WP, Kirkland JL, Passos JF, von Zglinicki T, Jurk D