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However, the exogenous application of GSH significantly increased the activities of MDHAR, DHAR, and GR in rice plants, except for the MDHAR and GR activities of the roots, compared with the As-alone treatment ( Figure 3 )

Reviewer #1 The present manuscript describes the role of the GHSR in intracellular signaling on its own and in a variety of molecular interactions with other receptors as well as the potential for stimulation of GHSRs as a therapeutic target for a wide-range of clinical conditions

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