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Doping with Ag/Zn or green synthesis with plant extracts further reduces required copper doses, enhancing biocompatibility (Kasi et al., 2024

Subsequently, oral substitution treatment with betaine was initiated at a dosage of 3 g/day, which was slowly increased to 9 g/day

Ultimately, by addressing both the mechanical and biological aspects of healing, these new techniques aim to provide patients with more reliable long-term stability and a faster return to their daily lives