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Cytosolic glutamate is critical for GSH synthesis, which in turn functions as reducing substrate for GPX4, an essential enzyme to protect the cell against oxidative damage (Figure 1A)

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Additionally, ROS can promote endothelial fibrosis, resulting in downregulation of adhesion proteins, thereby compromising endothelial integrity and increasing permeability (48)

+ Most patients notice a lift in energy and mental clarity within two to seven days of the first injection, though the response is more pronounced in patients who were running low to begin with