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GPx1 is a major antioxidant enzyme whose main biological role is to protect organisms from oxidative damage by scavenging hydrophilic peroxide species such as H 2 O 2 40

10.1038/nrd3531 200

Moreover, our biochemical and genetic analysis, including the generation of Il1b K133R/K133R mice, highlight that IL-1 K133 ubiquitylation limits IL-1 levels and therefore Caspase-1-mediated activation both in vitro and in vivo