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These primary data suggest that carriers of the Thr92Ala polymorphism may experience inadequate intracerebral T3 availability despite standard replacement therapy, contributing to persistent symptoms

doi:10.1016/B978-0-12-385853-5.00001-5

Signs and symptoms of toxicity (1, 5) Garlic odor in the breath Metallic taste in the mouth Hair and nail loss or brittleness Lesions and rashes on the skin Nausea Diarrhea Mottled teeth Fatigue Irritability Nervous system abnormalities Acute selenium toxicity in humans is rare, but intentional or accidental ingestion of large amounts of selenium can be fatal

2016 meta-analysis: Nine RCTs in 911 participants found carnitine supplementation resulted in 1.33 kg more weight loss than placebo [3][63]