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Developing novel inducers with better pharmacokinetic properties or repurposing FDA-approved anticancer drugs with cell death-inducing activity may partially solve these limitations

Mechanisms of MHC-I downregulation and role in immunotherapy response

Kathad U, Biyani N

During this process, partial electron transfer via NADPH-CYP450 reductase to the CYP450-substrate complex results in "electron leakage", leading to the incomplete reduction of O to O 2 or HO [129]