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Therefore, pyroptosis is more prominent during acute exacerbations or active lesions of periodontitis (69)

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In cellular studies, supplementation with L-serine significantly upregulates osteogenic markers such as alkaline phosphatase, Runx2, osterix, and type 1 collagen) in osteoblasts, indicating accelerated differentiation, whereas D-serine exposure suppresses osteoclast markers like cathepsin K, indicating reduced bone resorptive activity [9]

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