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The most common adverse reactions or laboratory abnormalities leading to interruption of pemetrexed in this arm (2%) were neutropenia (12%), anemia (7%), asthenia (4%), pneumonia (4%), thrombocytopenia (4%), increased blood creatinine (3%), diarrhea (3%), and fatigue (3%)

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Seventeen studies were conducted in hospital settings, and the remaining 8 in university hospital settings

The frequency of injections depends on individual needs and medical advice, but many people receive injections once a week if they are deficient