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233 Sodium-glucose cotransporter-2 (SGLT2) inhibitors are commonly used for type 2 diabetes treatment, and in recent years, SGLT2 inhibitors canagliflozin has been shown to suppress IL-6 and IL-1 levels and MPO enzyme activity in the colon of UC rats by downregulating the expression of NF-B p65, thereby reducing colonic inflammatory cell infiltration and oxidative stress

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Similarly, IL-1-induced BMSC-Exos reversed hemin-induced ferroptosis in neuronal cells, including high iron, ROS, malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), and reduced GSH level and cell viability [143]