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Transcobalamin deficiency impairs the transport of B12 into cells, resulting in inadequate utilization of the vitamin despite sufficient levels in the bloodstream

17 Rosenstock, J., et al., Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial