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Loss of function of CAV1 cause Berardinelli-Seip congenital lipodystrophy and congenital generalized lipodystrophy type 3 (OMIM #612526), characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis, and early onset of diabetes [43]

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The ability to extend the half-life, for example, would be particularly important for a proteins use in gene therapy, transgenic animal production, the bioprocess production and purification of the protein, and use of the protein as a chemical modulator among others