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Moreover, the upregulation of HK2 in the liver confers protection against liver IR injury mediated by RIPK1 kinase, while depleting HK2 in HCC cells enhances TNF-induced cell death and synergistically improves the efficacy of anti-PD1 therapy in an HCC model

Cystine starvation-induced GPX4 protein downregulation was mediated by protein translation suppression rather than reduction in mRNA transcription or protein stability