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Additionally, immunostaining with anti-Ly6C revealed a decrease in Ly6C + monocytes within the plaque of P-Mn/TI@mHSA-treated mice (Supplementary Fig

This clearly implies that, although several in vitro tests for genotoxicity assessment are available at different stages of development and acceptance, they cannot be considered to fully replace animal tests needed to evaluate the safety of substances (see Adler et al., 2011)

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Accordingly, studies have found that increased circulating levels of TNF- correlate positively with the antidepressant effects observed after a 12-week aerobic exercise regimen