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Front Biosci 13:72107226

Additionally, BER prevents the activation of the LRR, NACHT, and PYD domain-containing protein 3 (NLRP3) inflammasome during PD-related inflammation and restores autophagy activity that safeguards dopamine neurons [24]

Another mechanism that may contribute to the antioxidant activity of phenolic compounds is their ability to chelate redox active metal ions, such as iron, cobalt, manganese, or copper, thus preventing reactions catalyzed by these ions that lead to the formation of oxidative species that can generate oxidative damage at different cellular levels

Metabolomic-guided personalization offers a promising translational pathway