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As a pivotal link in inflammation, mitochondrial dysfunction has been closely associated with the onset and progression of various types of inflammatory arthritis, including RA (10)

n is an integer from 1 to 12 the terminal nitrogen is optionally further substituted with R 3 , wherein R 3 is selected from the group consisting of hydrogen, oxygen, hydroxyl, and C 1 -C 6 alkyl

It would be quite interesting to follow these studies with an investigation of brain mitochondria and estrogen receptors to determine whether sex steroid hormones in the brain might be involved in the gender differences seen in the prevalence of depression

Following single oral doses R , S -lipoic acid (racemic mixture), peak plasma concentrations of R -lipoic acid were found to be 40%-50% higher than S -lipoic acid, suggesting a differential absorption in favor of the R -enantiomer (6, 8, 11)