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Notably, a Western diet (rich in saturated fatty acids) did not induce intestinal inflammation in Gpx4 +/IEC mice (Fig

To determine if GABA reduction in the sensorimotor cortex is associated with dysfunction of supraspinal GABAergic neurons, we performed transcranial magnetic stimulation studies to assess intracortical inhibition and excitation [20]

Amino acid profiling siblings discordant for konzo identifies deficiencies in key sulfur amino acids and suggests mitochondrial distress To determine if siblings discordant for konzo had major differences in amino acid profiles which may contribute to changes in GPx3 abundance, we used an HPLC-based approach to quantify plasma amino acids in samples from study participants

Abstract Background Glutathione s-transferases (GSTs) perform an essential role in detoxification of xenobiotics and endogenous compounds via their conjugation to reduce glutathione