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Benefits appear within the first few weeks and then increase synergistically with continued treatment

[120] In advanced disease, tamoxifen is now only recognized as effective in ER+ patients, but the early trials did not select ER+ patients, and by the mid-1980s the clinical trial picture was not showing a major advantage for tamoxifen

It is used to prevent and treat deficiencies in vitamin B1, B6, and B12

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