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We use the model system Drosophila, where virtually every gene can be targeted for knock-out or activation in a cell type selective manner Drosophila also offers the advantage that its brain is composed of a relatively small number of stereotyped neuronal lineages, groups of neurons descended from individual embryonic stem cells, called neuroblasts

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Specifically, abnormal DNA methylation patterns contribute to amyloid-beta (A) and phosphorylated tau protein aggregation, thereby fostering plaques and tangles formation (159)

At the molecular level, research reveals that inflammation and immune dysregulation, oxidative stress and metabolic disorders, epigenetic modifications, and cellular structural and functional damage collectively form the intricate pathological network of diabetic nephropathy