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Protocol [2] CCl 4 aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted

Actually the structures of U46C GPx4 mutant and rhGPx3 mutant are quite similar (Figure 4a) although their sequence identity is only 34%

this is not an overnight transformation, but the cumulative effect over several months is significant for many patients

Dauer W, Kholodilov N, Vila M, Trillat AC, Goodchild R, Larsen KE, Staal R, Tieu K, Schmitz Y, Yuan CA, Rocha M, Jackson-Lewis V, Hersch S, Sulzer D, Przedborski S, Burke R, Hen R, 2002