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Acta Pharmacol Sin 46(8):21052119

Prior studies suggest that there is an association between stress from early adverse life events and the development of irritable bowel syndrome (IBS), a functional disorder associated with a higher intestinal permeability [93, 94]

It is a self-sustaining system consisting of small molecules such as vitamins E and C, glutathione 59,60 , and antioxidative defense enzymes, such as superoxide dismutase 61 , catalase 62,63 , glutathione peroxidase, glutathione reductase, and glutathioneS-transferases 62