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Similarly, a recent meta-analysis of 15 cohort studies with over 86,000 PD cases and nearly 30 million subjects, found that prediabetic patients have a 4% increased risk of PD compared to individuals with normal blood glucose level [20]

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Gut microbes produce or metabolize a spectrum of bioactive compounds, including SCFAs, bile acids, and tryptophan derivatives, which collectively influence energy homeostasis, insulin sensitivity, and sex hormone balance

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