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doi: 10.1186/s12967-023-04554-0 21 WangHAhnKSAlharbiSAShairOHArfusoFSethiGet al

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A post-hoc analysis of the CARES clinical trial was recently published, showing a reduction of CKD progression (a drop in GFR of 0.5 ml/min/year) in patients with gout treated with allopurinol or febuxostat who maintained a UA level of less than 6 mg/dL for a median of 2.5 years.50 These data could suggest that the deposits of monosodium urate crystals in the kidneys may be responsible for the progression of kidney disease

The optimal timing for oral glutathione is 12 hours before drinking begins (to pre-load hepatic reserves), immediately before bed (to support overnight acetaldehyde clearance), and upon waking (to address residual oxidative stress)