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McGill JB (2012) Linagliptin for type 2 diabetes mellitus: a review of the pivotal clinical trials

[10] The first amylin analogue to reach the clinic, pramlintide, demonstrated that the pathway could be drugged, but native-style amylin analogues are short-acting and were used as multiple-daily injections, which limited their appeal for weight management

Oral forms must pass through the digestive system, which can lead to variability in absorption, while injectable or IV forms enter the bloodstream directly under medical supervision