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System X-c(-)/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

Initiator caspases possess a longer N-terminal pro-domain structure that enables them to form a protein platform that regulates caspase activation, such as the interaction between the pro-domain of caspase-9 and Apoptotic Protease-Activating Factor 1 (APAF-1) along with cytochrome c (Cyt c), which initiates apoptotic bodies [86]