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Skeletal muscle can release medium-chain acylcarnitines (MCACs) into the circulation to remove acyl-CoA, which can be detrimental to cellular function, particularly when the supply of energy substrates exceeds the oxidative capacity of the TCA cycle

Consequently, high-energy-demanding cells exhibit greater reliance on mitochondrial network stability, rendering them especially vulnerable to its dysregulation (Mosharov et al

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