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GHK-Cu, in contrast, delivers copper(II) ions to metalloenzymes such as lysyl oxidase (critical for collagen and elastin cross-linking), superoxide dismutase (antioxidant defense), and cytochrome c oxidase (mitochondrial respiration)

Cancer 127:18161826 Moreau P, Dimopoulos MA, Mikhael J, Yong K, Capra M, Facon T et al (2022) Updated progression-free survival (PFS) and depth of response in IKEMA, a randomized phase III trial of isatuximab, carfilzomib and dexamethasone (Isa-Kd) vs Kd in relapsed multiple myeloma (MM)

Remarkably, in both human and mouse macrophages, the addition of FA 24:1 was enough to significantly improve the efferocytosis ability of M1 macrophages in a dose-dependent manner, but it had no further enhancement on M2 macrophages, which already have high efferocytosis capacity (Fig

The goal is support, not overstimulation